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vLLM is an inference and serving engine for large language models (LLMs). Prior to 0.22.0, an assert-based security check in vLLM's activation function loading allows any unauthenticated attacker to achieve arbitrary code execution on the server by publishing a malicious HuggingFace model, when vLLM runs in Python optimized mode (python -O or PYTHONOPTIMIZE=1). This vulnerability is fixed in 0.22.0.