Adversaries may achieve persistence by leveraging Python’s startup mechanisms, including path configuration (`.pth`) files and the `sitecustomize.py` or `usercustomize.py` modules. These files are automatically processed during the initialization of the Python interpreter, allowing for the execution of arbitrary code whenever Python is invoked.(Citation: Volexity GlobalProtect CVE 2024) Path configuration files are designed to extend Python’s module search paths through the use of import statements. If a `.pth` file is placed in Python's `site-packages` or `dist-packages` directories, any lines beginning with `import` will be executed automatically on Python invocation.(Citation: DFIR Python Persistence 2025) Similarly, if `sitecustomize.py` or `usercustomize.py` is present in the Python path, these files will be imported during interpreter startup, and any code they contain will be executed.(Citation: Python Site Configuration Hook) Adversaries may abuse these mechanisms to establish persistence on systems where Python is widely used (e.g., for automation or scripting in production environments).
Defender observes unauthorized modification or creation of Python hook files such as `.pth`, `sitecustomize.py`, or `usercustomize.py` in Python `site-packages`, `dist-packages`, or user paths. This is often correlated with subsequent unexpected interpreter execution (e.g., python3 running without user interaction), changes in interpreter behavior (e.g., malicious imports), and outbound connections initiated from Python. Defender links write/modify actions on hook files with execve of python process and/or anomalous child process or network activity.